Mannoheptulose: glycolytic inhibitor and novel caloric restriction mimetic

A novel caloric restriction mediator

Caloric restriction in humans.

Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a protective effect against secondary aging, and markedly decreases the incidence of malignancies. However, the only way to determine whether CR "works" in humans is to conduct studies on people. Such studies are difficult to perform in free-living people. While research on CR in humans is still at...

[Caloric restriction and anti-aging].

エレガンス線虫の寿命は約 3 週間で寿命の遺伝学的解 析に適している.研究室で実験に使っている野生型線虫 (N2)は,20°C で飼育すると,最大寿命が 21 日前後な ので,10 日目には中年特有の表現系を示すことが知ら れている.実際,顕微鏡で観察すると,10 日目には消 化管の周りの脂肪組織が急に黒ずんで目立つようにな る.この症状は脂肪細胞にトリグリセライドの蓄積が増 加するためで,ヒトにおける中年太りの内臓脂肪の蓄積 によく似た症状である. 代表的な長寿線虫,daf-2 変異体は最も遺伝解析が進 んでいる変異体である.daf-2 線虫は耐性幼虫(dauer) になりやすいことから daf(dauer formation,耐性幼虫 化)シリーズの名前が付いている.しかし,運動やリズ ムは正常で,一定温度(高温)で飼育する限り,耐性幼 虫化せずに,寿命は 1.5 倍~2 倍に延...

Caloric restriction and its mimetics

Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being con...

Caloric Restriction Mimetic 2-deoxy-glucose Antagonizes Doxorubicin- Induced Cardiomyocyte Death through Multiple Mechanisms

CALORIC RESTRICTION MIMETIC 2-DEOXY-GLUCOSE ANTAGONIZES DOXORUBICININDUCED CARDIOMYOCYTE DEATH THROUGH MULTIPLE MECHANISMS Kai Chen, Xianmin Xu, Satoru Kobayashi, Derek Timm, Tyler Jepperson, Qiangrong Liang* Cardiovascular Health Research Center, Sanford Research/USD, Sioux Falls, South Dakota 57104 Running title: 2-Deoxy-Glucose Inhibits Doxorubicin-induced Cardiomyocyte Death *Address Corres...